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APC inhibidores (APC Inhibitors)

Anaphase-Promoting Complex (APC) which is also called cyclosome, a highly conserved protein, plays a key role in both cell cycle and Ubq degradation pathway. The APC can results in degradation of specific proteins which are involved in cell cycle by tagging those proteins during the transition from metaphase to anaphase. When spindle checkpoint is silenced, APC can easily bind to Cdc20 after phosphorylated by M-Cdks. Then APC targets cyclin A and cyclin B for degradation.

Otro Cell Cycle Inhibidores

CDK ROCK Wee1 Aurora Kinase Chk PLK MPS1 Rho Myc DYRK
Nº Cat. Nombre del producto Información Citas de uso del producto Validaciones del producto
S2225 TAME El Tosyl-L-Arginine Methyl Ester (TAME) es un inhibidor de la APC.
Dev Cell, 2023, 58(3):192-210.e11
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
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S9605 Apcin Apcin (inhibidor de APC) es un inhibidor de la actividad E3 Ligase del complejo promotor de la anafase/ciclosoma (APC/C) mitótico que se une a Cdc20 e inhibe competitivamente la ubiquitinación de sustratos que contienen una caja D.
Nature, 2025, 647(8091):952-961
Theranostics, 2025, 15(8):3439-3461
Cell Mol Biol Lett, 2025, 30(1):29