Pim3 Inhibitors
- Pim1
- Pim2
- Pim3
| Nº Cat. | Nombre del producto | Información | Selectivo / Pan | IC50 / Ki |
|---|---|---|---|---|
| S7104 | AZD1208 | AZD1208 is a potent, and orally available Pim kinase inhibitor with IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3, respectively. Phase 1. | Pan | Pim3, IC50: 1.9 nM |
| S7041 | CX-6258 HCl | CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively. | Pan | Pim3, IC50: 16 nM |
| S2198 | SGI-1776 free base | SGI-1776 is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1. | Pan | Pim3, IC50: 69 nM |
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