Home JAK/STAT -Apoptosis -Stem Cells & Wnt STAT STAT3-Selectivo Inhibitors

STAT3-Selectivo Inhibitors

  • STAT1
  • STAT3
  • STAT5
Nº Cat. Nombre del producto Información Selectivo / Pan IC50 / Ki
S3030 Niclosamide Niclosamide can inhibit DNA replication and inhibit STAT with IC50 of 0.7 μM. Selective STAT3, IC50: 0.7 μM
S2285 Cryptotanshinone Cryptotanshinone (CPT) is a STAT3 inhibitor with IC50 of 4.6 μM, strongly inhibits phosphorylation of STAT3 Tyr705, with a small effect on STAT3 Ser727, but none against STAT1 nor STAT5. Selective STAT3, IC50: 4.6 μM
S7024 Stattic Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM, highly selectivity over STAT1. Selective STAT3, IC50: 5.1 μM
S1155 S3I-201 S3I-201 shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM, and low activity towards STAT1 and STAT5. Selective STAT3, IC50: 86 μM
S7501 HO-3867 HO-3867, an analog of curcumin, is a selective STAT3 inhibitor. Selective
S7337 SH-4-54 SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively. Pan STAT3, Kd: 300 nM
S4182 Nifuroxazide Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells Pan