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Elamipretide (SS-31, MTP-131)

Nº de cat.S9803

Elamipretide (MTP-131, SS-31) is a cytochrome c peroxidase inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.

Secuencia de aminoácidos

Elamipretide (SS-31, MTP-131) Amino-acid Sequence

Número CAS 736992-21-5

Selleck's Elamipretide (SS-31, MTP-131) Ha sido citado por 16 Publicaciones

Control de calidad

Lote: Pureza: 99.37%

99.37

Información química y solubilidad

Almacenamiento (desde la fecha de recepción)	3 years -20°C powder	Almacenamiento de soluciones madre Alícuote las soluciones madre para evitar ciclos repetidos de congelación-descongelación	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vitro
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Water : 100 mg/mL

Calculadora de peso molecular

In vivo
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Agregue los solventes al producto individualmente y en orden.

Calculadora de Formulación In vivo

Actividad biológica

Descripción	Elamipretide (MTP-131, SS-31) is a cytochrome c peroxidase inhibitor. Elamipretide improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice.
Targets/IC₅₀/Ki	cytochrome c peroxidase

In vitro
In vitro	Elamipretide (SS-31, MTP-131) binds with high affinity to cardiolipin, an anionic phospholipid expressed on the inner mitochondrial membrane that is required for cristae formation. In addition, the complex of this compound with cardiolipin inhibits cytochrome c peroxidase activity, which catalyzes cardiolipin peroxidation and results in mitochondrial damage during ischemia, by protecting its heme iron.
Investigación celular	Líneas celulares	feline kidney cells
	Concentraciones	0.1-10 μM
	Tiempo de incubación	1 hour
	Método	Intracellular targeting of Elamipretide (SS-31, MTP-131) is determined by incubating feline kidney cells, grown in biotin-free media for 24 hours, with biotinylated compound for 1 hour. Cells are then fixed with 4% paraformaldehyde, permeabilized with 0.1% triton, and treated with Streptavidin-AlexaFluor594 for 30 minutes at room temperature. Fluorescence staining is observed by wide-field fluorescent microscope.

In vivo
In vivo	Pretreatment of rats with Elamipretide (SS-31, MTP-131) protects cristae membranes during renal ischemia and prevents mitochondrial swelling. Prompt recovery of ATP on reperfusion leads to rapid repair of ATP-dependent processes, such as restoration of the actin cytoskeleton and cell polarity. Rapid recovery of ATP also inhibits apoptosis, protects tubular barrier function, and mitigates renal dysfunction.
Investigación en animales	Modelos animales	male Sprague–Dawley rats
	Dosificaciones	2.0 mg/kg
	Administración	SC

Referencias
https://pubmed.ncbi.nlm.nih.gov/23813215/ https://pubmed.ncbi.nlm.nih.gov/31747905/

Referencias

https://pubmed.ncbi.nlm.nih.gov/23813215/
https://pubmed.ncbi.nlm.nih.gov/31747905/

Información del producto

Fórmula molecular	C₃₂H₄₉N₉O₅
Peso molecular	639.79
Número CAS	736992-21-5
Almacenamiento (Desde la fecha de recepción)	3 years -20°C powder
Envío	Envío a temperatura ambiente (las pruebas de estabilidad muestran que este producto puede enviarse sin ninguna medida de enfriamiento.)