WZ811

N.º de catálogoS2912 Lote:S291201

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Datos técnicos

Fórmula

 

C18H18N4
 
Peso molecular 290.36 Número CAS 55778-02-4
Solubilidad (25°C)* In vitro DMSO 30 mg/mL (103.32 mM)
Water Insoluble
Ethanol Insoluble
In vivo (Agregue los solventes al producto individualmente y en orden.)
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O

Validado por los laboratorios Selleck. Si necesita ajustes en esta formulación, póngase en contacto con nuestro equipo de ventas para pruebas personalizadas.

 1.500mg/ml (5.17mM) Taking the 1 mL working solution as an example, add 50 μL of 30 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml significa ligeramente soluble o insoluble.
* Tenga en cuenta que Selleck prueba la solubilidad de todos los compuestos internamente, y la solubilidad real puede diferir ligeramente de los valores publicados. Esto es normal y se debe a ligeras variaciones entre lotes.
* Envío a temperatura ambiente (Las pruebas de estabilidad demuestran que este producto se puede enviar sin medidas de refrigeración.)

Preparación de soluciones madre

Actividad biológica

Descripción WZ811 es un antagonista competitivo de CXCR4 altamente potente con una EC50 de 0,3 nM.
Objetivos
CXCR4
0.3 nM(EC50)
In vitro WZ811 es un antagonista competitivo altamente potente de CXCR4. Este compuesto es eficaz para contrarrestar el SDF-1 en la reducción de cAMP a dosis tan bajas como unos pocos nanomoles. Bloquea la invasión mediada por SDF-1 con una EC50 de 5,2 nM.

Protocolo (de referencia)

Referencias

  • https://pubmed.ncbi.nlm.nih.gov/17958344/

Validación de productos por parte del cliente

<p>Gelatin degradation by COR-L23 (f) cells treated with 1 μM PF-573228 and 1 μM WZ811. Histograms showing percentages of degraded gelatin areas relative to the cell volume for each cell line are presented together with representative images. Merged channels show fluorescent gelatin (green), actin (red) and nuclei (blue) staining; dark areas represent spots of degraded gelatin. Scale bar = 100 μm.</p>

, , Invest New Drugs, 2017, 35(6):718-732

Cell growth inhibition of non-small cell lung carcinoma (NSCLC) by CXCR4 anatgonist WZ811. Two lung cancer cell lines were treated with WZ811: HTB183 – derived from large cell lung carcinoma metastasis in lymph node and A549 – derived from lung adenocarinoma. Both cell lines showed similar response to WZ811. This implies that this CXCR4 antagonist acts similarly on different lung cancer subtypes.

, , Dr.Milica Pesic from Institute for Biological Research

The effects of SelleckChem inhibitors on sea urchin embryo development evaluated 24 h after fertilization. All compounds were added to embryos suspension 20 min after fertilization. The relative presence of late gastrula, swimming blastula, undeveloped embryos and dead embryos was compared next to untreated control embryos (A). Fertilized egg, swimming blastula and late gastrula are illustrated (B). The embryonic development was relatively synchronized in untreated control samples after 24 h (A, E). GSK690693 treatment sustained the development of embryos. Swimming blastulas kept normal motility regardless the deformities in their shape. Tipifarnib treatment induced significant toxicity due to occurrence of dead fragmented embryos. Some abnormal blastulas kept the motility. AZD2014 treatment sustained the development of embryos. Some developed gastrulas and blastulas were less motile in comparison with control (A, C). WZ811 was the least toxic compound. Significant number of gastrulas and blastulas was developed. However, their motility was considerably suppressed (A, D). In contrast to SelleckChem inhibitors, classic anticancer agent – cisplatin was extremely toxic to sea urchin embryos (A). Cisplatin killed many embryos, while a small amount of survived embryos was stopped at early phases of development: immediately after fertilization or after first and second division (A, F).

, , Dr. Milica Pesic from Institute for Biological Research

<p> </p><p> </p><p>WZ 811 and Tipifarnib inhibit the cell growth of anaplastic thyroid carcinoma cell lines (FRO and SW1736). There is no difference in sensitivity of tested cell lines to WZ 811, while FRO cells are more sensitive to Tipifarnib in comparison with SW1736 cells. Both cell lines are p53 null. FRO cells possess mutated HRas and SW1736 cells possess mutated BRaf.</p>

,

Sellecks WZ811 Ha sido citado por 20 Publicaciones

Immunoglobulin-like transcript 2 as an impaired anti-tumor cytotoxicity marker of natural killer cells in patients with hepatocellular carcinoma [ Front Immunol, 2024, 15:1389411] PubMed: 38638429
MicroRNA-301a knockout attenuates peripheral nerve regeneration by delaying Wallerian degeneration [ Neural Regen Res, 2024, 10.4103/NRR.NRR-D-24-00081] PubMed: 39101651
Exploring the Interplay of RUNX2 and CXCR4 in Melanoma Progression [ Cells, 2024, 13(5)408] PubMed: 38474372
Modeling the SDF-1/CXCR4 protein using advanced artificial intelligence and antagonist screening for Japanese anchovy [ Front Physiol, 2024, 15:1349119] PubMed: 38370015
Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis [ Cell Discov, 2023, 9(1):104] PubMed: 37848438
Berbamine targets cancer stem cells and reverses cabazitaxel resistance via inhibiting IGF2BP1 and p-STAT3 in prostate cancer [ Prostate, 2023, 10.1002/pros.24632] PubMed: 37828768
The CXCR4-CXCL12 axis promotes T-cell reconstitution via efficient hematopoietic immigration [ J Genet Genomics, 2022, S1673-8527(22)00125-4] PubMed: 35483564
Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells [ Nat Commun, 2021, 12(1):652] PubMed: 33510160
TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment [ Cell Rep, 2020, 33(1):108221] PubMed: 33027668
Megakaryocytes participate in the occurrence of bleomycin-induced pulmonary fibrosis [ Cell Death Dis, 2019, 10(9):648] PubMed: 31501415

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