Palmitic acid

N.º de catálogoS3794 Lote:S379401

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Datos técnicos

Fórmula

C₁₆H₃₂O₂

Peso molecular

256.42

Número CAS

57-10-3

Solubilidad (25°C)*

In vitro

DMSO

51 mg/mL (198.89 mM)

In vivo (Agregue los solventes al producto individualmente y en orden.)

Homogeneous suspension

CMC-NA

≥5mg/ml

Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

* <1 mg/ml significa ligeramente soluble o insoluble.
* Tenga en cuenta que Selleck prueba la solubilidad de todos los compuestos internamente, y la solubilidad real puede diferir ligeramente de los valores publicados. Esto es normal y se debe a ligeras variaciones entre lotes.
* Envío a temperatura ambiente (Las pruebas de estabilidad demuestran que este producto se puede enviar sin medidas de refrigeración.)

Preparación de soluciones madre

Actividad biológica

Descripción	Palmitic acid (Hexadecanoic acid, Cetylic acid) is the most common saturated fatty acid found in animals, plants and microorganisms with anti-tumor activity. This compound is a fatty acid that is almost insoluble in water-soluble solvents such as culture medium. It needs to be emulsified before use in cell experiments. It is recommended to purchase it in powder form.
In vitro	Palmitic acid (PA) binds TLR4 via the adaptor protein MD2 and that the TLR4 signal induced by this compound stimulates dendritic cells activation and maturation accompanied by a robust IL-1β response. It is a TLR4/MD-2 ligand. This chemical exerts pro-inflammatory activity through TLR4.
In vivo	In a dose-dependent fashion, palmitic acid rapidly reduces mouse locomotor activity by a mechanism that did not rely on TLR4, MyD88, IL-1, IL-6 or TNFα but is dependent on fatty acid chain length. This compound induces anxiety-like behavior in mice while increasing amygdala-based serotonin metabolism.

Protocolo (de referencia)

Ensayo celular:^{^[3]}	Líneas celulares The insulinoma cell line INS-1 Concentraciones 250 μmol/L Tiempo de incubación 24 or 48 h Método The INS-1 cells are seeded onto 96-well plates at 4,000 cells/well with 10% BSA and incubated with T0901317 (10 μmol/L), palmitic acid (250 μmol/L), a combination of T0901317 and this compound or PBS (mock control) for 24 or 48 h. After the treatment incubation, 20 μl of MTT solution (5 mg/mL MTT in PBS, pH 7.4) are added to each well, followed by incubation at 37°C for 4 h. The supernatants are removed from the wells and DMSO (15 μl/well) is added to dissolve the crystals. The optical density at a wavelength of 490 nm is measured using a microplate reader.
Estudio en animales:^{^[2]}	Modelos animales C57BL/6J mice Dosificaciones 0.3, 3, and 30 μmol/mouse Administración i.p.

Ensayo celular:^{^[3]}

Líneas celulares
The insulinoma cell line INS-1
Concentraciones
250 μmol/L
Tiempo de incubación
24 or 48 h
Método
The INS-1 cells are seeded onto 96-well plates at 4,000 cells/well with 10% BSA and incubated with T0901317 (10 μmol/L), palmitic acid (250 μmol/L), a combination of T0901317 and this compound or PBS (mock control) for 24 or 48 h. After the treatment incubation, 20 μl of MTT solution (5 mg/mL MTT in PBS, pH 7.4) are added to each well, followed by incubation at 37°C for 4 h. The supernatants are removed from the wells and DMSO (15 μl/well) is added to dissolve the crystals. The optical density at a wavelength of 490 nm is measured using a microplate reader.

Estudio en animales:^{^[2]}

Modelos animales
C57BL/6J mice
Dosificaciones
0.3, 3, and 30 μmol/mouse
Administración
i.p.

Referencias

https://pubmed.ncbi.nlm.nih.gov/28463985/
https://pubmed.ncbi.nlm.nih.gov/25016520/
https://pubmed.ncbi.nlm.nih.gov/21753123/

Selleck's Palmitic acid Ha sido citado por 11 Publicaciones

SLC25A1 reprograms mitochondrial and fatty acid metabolism to promote the progression of acute myeloid leukemia [ Haematologica, September 04, 2025, Ahead of print]	PubMed: 40905075
Myristic acid as a checkpoint to regulate STING-dependent autophagy and interferon responses by promoting N-myristoylation [ Nature Communications, February 07, 2023, 660]	PubMed: 36750575
Stromal Cell Derived Factor-1 Promotes Hepatic Insulin Resistance via Inhibiting Hepatocyte Lipophagy [ J Cell Mol Med, 2025, 29(2):e70352]	PubMed: 39855896
Ginkgolide B attenuates hyperlipidemia by restoring sphingolipid homeostasis and activating PPARα and Nrf2 pathways [ Sci Rep, 2025, 15(1):28774]	PubMed: 40770408
Quercetin alleviates metabolic-associated fatty liver disease by tuning hepatic lipid metabolism, oxidative stress and inflammation [ Anim Biotechnol, 2025, 36(1):2442351]	PubMed: 39718035
Prenatal valproic acid on the basis of gestational diabetes also induces autistic behavior and disrupts myelination and oligodendroglial maturation slightly in offspring [ Research Square, 2024, 10.21203/rs.3.rs-3480364/v1]	PubMed: none
Myristic acid as a checkpoint to regulate STING-dependent autophagy and interferon responses by promoting N-myristoylation [ Nat Commun, 2023, 14(1):660]	PubMed: 36750575
Palmitic acid induces nDNA release to cytosol and promotes microglial M1 polarization via cGAS-STING signaling pathway [ Biochim Biophys Acta Mol Cell Res, 2023, 1870(1):119385]	PubMed: 36302463
FGF9 Alleviates the Fatty Liver Phenotype by Regulating Hepatic Lipid Metabolism [ Front Pharmacol, 2022, 13:850128]	PubMed: 35517790
GDF11 rapidly increases lipid accumulation in liver cancer cells through ALK5-dependent signaling [ Biochim Biophys Acta Mol Cell Biol Lipids, 2021, 1866(6):158920]	PubMed: 33684566

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